Comma splicing
✗ She has an advanced degree in biochemistry, therefore, she’s the best candidate.
✓ She has an advanced degree in biochemistry, and therefore is the best candidate.
✓ She has an advanced degree in biochemistry; therefore, she’s the best candidate.
✓ She has an advanced degree in biochemistry. Therefore, she’s the best candidate.
Omitting a semicolon
✗ The two lines intersect therefore, they are not parallel.
✓ The two lines intersect; therefore, they are not parallel.
Mistaking it for “therefor” (which means “for or in return for that”)
✗ The metal bracelet was made using mid-century welding techniques; therefor, it is a legitimate antique.
✓ The metal bracelet was made using mid-century welding techniques; therefore, it is a legitimate antique.
Using it in informal settings (this is not against the rules, but “so” sounds more natural)
✗ The trip was cancelled and, therefore, I visited my aunt instead.
✓ The trip was cancelled, so I visited my aunt instead.