How to Insert Progesterone Suppositories Without an Applicator

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Progesterone suppositories are often used during in vitro fertilization (IVF) treatments or to cause periods in perimenopausal adults who are low in progesterone. [1] The suppositories are made by a pharmacist and can be inserted either with or without an applicator. Make sure both your hands and vaginal area are clean before you insert your suppository. Follow all of your doctor’s instructions for using and storing your progesterone.

Part 1
Part 1 of 3:

Washing Up

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  1. Stand in your shower or bathtub and wet your vaginal area. Use your hand to apply the soap (washcloths or loofahs may irritate the sensitive skin). [2] After you lather, rinse with warm water until all of the soap is gone.
    • Your vaginal area can harbor bacteria and germs. You need to wash the area to make sure these bacteria and germs don’t enter your vagina when you insert the suppository.
    • Make sure your soap is unscented, as fragrances can cause irritation. [3]
  2. Wash your hands with soap and warm water. [4] Wet your hands with warm water and apply soap. Rub your hands together to create a lather, continuing for 20 seconds. Then, rinse your hands under warm running water until all of the soap is washed away. [5]
    • Your hands can also have germs and bacteria on them, and you don't want to transfer any germs or bacteria into your vagina.
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  3. Your suppository is made from progesterone suspended in a base. When it enters your body, the base melts and releases the progesterone. You don't want the suppository to melt in your warm hands, so handle it as little as possible before applying. [6]
    • It’s best to lightly hold your suppository between 2 fingers. Never hold it in your palm.
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Part 2
Part 2 of 3:

Pushing the Suppository into Your Vagina

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  1. [7] This helps open your vagina as much as possible so it's easier to insert the suppository. You'll be able to push it in deeper than you would in other positions, which helps it be more effective.
    • Pull your legs as far back as possible, rather than just bending your knees.
    Rallie McAllister, OB/GYN and Pregnancy Health Expert

    Thoroughly wash your hands first to avoid infection when inserting progesterone capsules vaginally without an applicator. Using one finger, insert the capsule as deep as is comfortable, typically 2 inches (5 cm). Relax your pelvic muscles to ease insertion by reclining with bent knees and feet flat. Promptly contact your provider if you have any vaginal irritation, bleeding, leakage, or ongoing issues administering the medication.

  2. You may be able to get your suppository to stick to the end of your finger. [8] If this doesn’t work, hold the suppository at the entrance to your vaginal canal, between the lips of the vagina. [9] Then, put the tip of your finger behind it to push it into your vagina.
    • Remember to use a light touch when handling the suppository, as it can easily melt in your hands.
  3. [10] This will likely be as far as your finger will go, as well. Insert the suppository by pushing upward and backward. [11] If you feel any resistance, stop pushing and leave the suppository where it is. [12]
    • You should not feel any pain or discomfort when you insert the suppository. If you do, stop pushing and remove your finger.
  4. Slide your finger out, leaving the suppository in place. Make sure you don’t remove any of the medicine when you pull out your finger.
    • It's unlikely that the suppository will stay stuck to your finger. If this happens, however, re-insert the suppository into your vagina. Press against the sidewall of your vagina to help it stick.
  5. Relax in a lying down position for a moment before getting up. [13] The suppository will start melting immediately after you insert it into your vagina.
    • You don't need to stay lying down after you insert the suppository.
  6. [14] Scrub your hands with soap and water for 20 seconds, then rinse them clean in warm, running water. This will prevent the progesterone from absorbing into the skin on your hands and fingers. [15]
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Part 3
Part 3 of 3:

Using Your Medicine as Directed

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  1. Follow all of the instructions provided by your doctor and pharmacist. The instructions for using progesterone can vary depending on your individual needs, so do as your doctor directed. [16]
    • Your suppositories should look like ovals or bullets. They’re usually prepared by the pharmacist, so check with them if you have any questions.
  2. If you miss a dose of your progesterone, take it as soon as you remember. It’s important to take your medicine as directed, without missing a dose. However, don’t take two doses at once. [17]
    • If it’s close to your next scheduled dose, skip the dose you forgot to take and get back on schedule with your next dose.
  3. The progesterone will keep your vaginal area moist, as it will slowly leak out of your vagina. Wear cotton underpants and loose skirts or pants until you’re finished with your medication.
    • While using vaginal progesterone, don’t wear tight pants, nylon underwear, or tights. These materials don’t breathe, so they increase your risk of developing a yeast infection. [18]
  4. The suppository will melt inside your body and may slowly leak out of your vagina. You can wear a sanitary pad to protect your underwear from the leakage. [19]
    • Remember to change your pad every few hours. You want to keep your vaginal area as dry as possible, which will help prevent a yeast infection.
    • If you use your suppository right before bedtime, you will experience less discharge than if you walk around after you insert it.
  5. Tampons can absorb the progesterone, which can limit how effective it is. Always use sanitary pads rather than tampons. [20]
    • You might start your period while you’re using the progesterone. If this happens, continue to use sanitary pads only. Don’t use tampons.
  6. It’s best to store your suppositories in the cool, dry conditions in your refrigerator. This helps them hold their form and makes them easier to insert, as they can easily melt. [21]
    • Some progesterone suppositories can be stored at room temperature. Check the label on your medication to be sure.
    • Don’t freeze your suppositories.
  7. Although progesterone is considered safe, all medicines come with risks. Your doctor can help you understand how your personal medical history relates to the risks of taking progesterone. Here are some risks your doctor may discuss: [22]
    • You shouldn't take progesterone during pregnancy unless it's prescribed as part of your fertility treatment.
    • Progesterone can increase your risk of developing blood clots, liver disease, stroke, heart attack, high blood pressure, breast cancer, or other side effects and conditions. This risk is greater if you have a personal or family history of these conditions.
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      Tips

      • Take your progesterone at the same time each day to make sure you use it as directed. [23]
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      • Notify your doctor if you become pregnant while using the progesterone suppositories. However, don’t stop taking the medication unless they tell you to. In most cases, you’ll continue the progesterone for about 10 weeks. [24]
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      References

      1. ↑ https://my.clevelandclinic.org/health/body/24562-progesterone
      2. ↑ https://www.womenswellness-sd.com/clean-lady-parts/
      3. ↑ https://uihc.org/educational-resources/vulvar-skin-care-guidelines
      4. ↑ https://my.clevelandclinic.org/health/drugs/20862-progesterone-vaginal-insert
      5. ↑ https://www.cdc.gov/clean-hands/about/index.html
      6. ↑ https://www.drugs.com/mtm/progesterone-vaginal.html
      7. ↑ https://www.mayoclinic.org/drugs-supplements/terconazole-vaginal-route/description/drg-20061411
      8. ↑ https://www.mayoclinic.org/drugs-supplements/terconazole-vaginal-route/description/drg-20061411
      9. ↑ https://www.medicines.org.uk/emc/product/5569/pil
      1. ↑ https://www.mayoclinic.org/drugs-supplements/terconazole-vaginal-route/description/drg-20061411
      2. ↑ https://www.medicines.org.uk/emc/product/5569/pil
      3. ↑ https://medlineplus.gov/druginfo/meds/a688022.html
      4. ↑ https://medlineplus.gov/druginfo/meds/a688022.html
      5. ↑ https://medlineplus.gov/druginfo/meds/a688022.html
      6. ↑ https://medlineplus.gov/druginfo/meds/a688022.html
      7. ↑ https://www.uofmhealth.org/health-library/d00550t1
      8. ↑ https://www.drugs.com/cdi/progesterone-vaginal-insert.html
      9. ↑ https://myhealth.alberta.ca/Health/aftercareinformation/pages/conditions.aspx?hwid=uf7069
      10. ↑ https://www.mayoclinic.org/drugs-supplements/terconazole-vaginal-route/description/drg-20061411
      11. ↑ https://www.uofmhealth.org/health-library/d03208a1
      12. ↑ https://fertilitycenteroforegon.com/progesterone-vaginal-suppositories-pvs/
      13. ↑ https://www.healthlinkbc.ca/medications/progesterone-suppository-vaginal
      14. ↑ https://www.healthlinkbc.ca/medications/progesterone-suppository-vaginal
      15. ↑ https://myhealth.alberta.ca/Health/medications/Pages/conditions.aspx?hwid=fdb0975
      16. ↑ https://my.clevelandclinic.org/health/drugs/20862-progesterone-vaginal-insert
      17. ↑ https://medlineplus.gov/druginfo/meds/a623013.html
      18. ↑ https://www.mayoclinic.org/drugs-supplements/progestin-oral-route-parenteral-route-vaginal-route/description/drg-20069443

      About This Article

      Article Summary X

      Progesterone suppositories are usually used during IVF treatment or to bring on your period. To insert one, you'll first need to wash your hands and your vaginal area with non-scented soap to reduce the risk of infection. Then, lie on your back with your legs up. Hold the suppository on the end of your fingers, but don’t hold it too long as it could melt. Push the suppository into your vagina as far as it will comfortably go. Afterwards, bring your legs back down and wash your hands. You should also wear a sanitary pad to catch any leakage. Choosing loose-fitting underwear is another good idea, since the suppository will keep your vaginal area moist. For tips from our Medical co-author on how to store your suppositories, read on!

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