How to Lower Ammonia Levels in the Body

Ammonia is a normal byproduct of digestion that is usually removed from the body by the liver. If you have elevated ammonia levels, it is typically due to a problem with your liver function. However, there are ways to decrease your ammonia levels and to improve your liver function. These include taking medication, supplementing your diet, and changing what you eat. With a combination of these methods, you can lower the ammonia levels in your body. [1]

Method 1
Method 1 of 3:

Medication

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  1. Most people that know they need to lower their ammonia levels find this out from their doctors. This problem is usually associated with another health problem, so controlling your ammonia levels will be part of an overall treatment plan. [2]
    • High ammonia levels are a common symptom of advanced liver disease (known as cirrhosis), and Reye's syndrome. If you have one of these diseases, it is likely that you will need to work on reducing your ammonia levels.
  2. Before taking medication for high levels of ammonia, you need to verify the problem. Ammonia tests measure the amount of ammonia in the blood, so a blood sample will be required. [3]
    • Normal ammonia levels range from 15 to 45 µ/dL (11 to 32 µmol/L). [4]
    • Ammonia levels temporarily rise after exercise, especially strenuous and long-lasting exercise like long-distance running. [5] Because of this, you should avoid exercise of all kinds as well as smoking before the test. [6]
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  3. Lactulose is a constipation medication that is used to treat high levels of ammonia in the blood. Lactulose works by removing ammonia from the blood and moving it into the colon. Once in the colon, the ammonia is eliminated from the body when you go to the bathroom. [7]
    • Follow your doctor's instructions for timing and dosage amount for ammonia removal. Typically, two 15 mL (1.0 US tbsp) doses of Lactulose are taken twice a day if you’re an adult. If your doctor has diagnosed you with hepatic encephalopathy, your dosage might be higher (30 to 50 mL (2.0 to 3.4 US tbsp) around 3 times per day). [8]
    • Lactulose is a liquid typically taken by mouth. [9] However, if you have extremely high levels of ammonia and are hospitalized, it may be administered with an enema directly into the digestive system. [10]
    • Lactulose is sold under a variety of brand names, including Duphalac, Enulose, Generlac, Constulose, and Kristalose. [11]
  4. While Lactulose does reduce ammonia in the blood, it also causes several side effects, including diarrhea, gas, and nausea. It was developed to treat constipation, so it pulls water out of the body and into the stool. This causes loose stools and other digestive complications. Talk to your doctor about what you can do to minimize these side effects. [12]
    • Be sure to hydrate regularly when taking Lactulose. The medication will pull a lot of water out of your body, so you should replace that liquid in order to avoid dehydration.
    • If your side effects are severe and impacting your quality of life, tell your doctor. This could signal that you need your dosage adjusted.
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Method 2
Method 2 of 3:

Diet

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  1. into your diet. Probiotics are beneficial bacteria that help you digest foods and protect you from disease. These bacteria can help your gut to digest and eliminate ammonia more effectively. [13] Some common foods that add probiotics into your diet include fermented dairy products, such as kefir, and fermented foods, such as sauerkraut. [14]
    • For example, try to eat a serving of yogurt every day. Yogurt is very high in probiotics and it can help your digestion, as well as your overall health. [15]
  2. Red meat protein is more likely to increase the ammonia in your blood than other types of animal proteins. If you know you have high ammonia levels, it's best to eat other types of meat, such as chicken. [16]
  3. Vegetable protein, such as that in beans, digests more slowly than protein that comes from animals. Therefore, your body has more time to dispose of the ammonia created while it is digested. With this in mind, it's best to choose vegetable proteins if you are working to keep your ammonia levels low.
    • Research shows that eating a vegetarian meal could help reduce ammonia levels for people struggling with severe liver disease. [17]
  4. Ammonia is a byproduct of protein digestion in the body. Because of this, it is important to limit your protein intake if you are experiencing particularly high levels of ammonia in the blood. High levels of ammonia are usually identified due to an increase in symptoms. [18]
    • For example, if you have liver disease and you are experiencing abnormal brain function, it's a good idea to limit your protein intake as you recover.
    • Confirm with your doctor that a low-protein diet is necessary for your recovery before embarking on one.
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Method 3
Method 3 of 3:

Supplements

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  1. Zinc can play an important role in increasing the amount of ammonia that your body is able to excrete. Talk to your doctor about whether a zinc supplement could help your ammonia levels decrease. [19]
    • Those with liver disease tend to have lower levels of zinc. Since zinc is an important part of normal ammonia disposal, supplementing zinc can help someone with high levels of ammonia get rid of it. [20]
  2. When you have high ammonia levels in the body, it is a signal that your body systems are not working correctly. This can cause a variety of health problems due to lack of essential vitamins and minerals. To offset this risk, talk to your doctor about taking a daily multivitamin that can give you many of the nutrients that you need.
    • Having your doctor approve your exact multivitamin and dosage will minimize the chance of you taking something that could have a negative impact on your liver function and ammonia levels. For instance, vitamin A in very high doses has been known to cause liver toxicity. [21]
  3. Glutamine supplements have been shown to decrease ammonia levels in endurance athletes. Talk to your doctor about whether taking this supplement might help manage your ammonia levels. [22]
    • Glutamine supplementation can be dangerous in people with liver failure. It’s important to discuss any supplements with your doctor before taking them. [23]
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      Warnings

      • It is important to reduce ammonia levels that are above normal. Having too much ammonia in the blood can cause severe health problems, such as decreased brain function. [24]
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      References

      1. ↑ https://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/hepatology/hepatic-encephalopathy/
      2. ↑ https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=ammonia
      3. ↑ https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=ammonia
      4. ↑ https://medlineplus.gov/ency/article/003506.htm
      5. ↑ https://www.ncbi.nlm.nih.gov/pubmed/18059593
      6. ↑ https://www.urmc.rochester.edu/encyclopedia/content.aspx?ContentTypeID=167&ContentID=ammonia
      7. ↑ https://my.clevelandclinic.org/departments/digestive/medical-professionals/hepatology/hepatic-encephalopathy#treatment-tab
      8. ↑ https://www.nhs.uk/medicines/lactulose/how-and-when-to-take-lactulose/
      9. ↑ https://www.nhs.uk/medicines/lactulose/how-and-when-to-take-lactulose/
      1. ↑ https://pubmed.ncbi.nlm.nih.gov/28929776/
      2. ↑ https://medlineplus.gov/druginfo/meds/a682338.html
      3. ↑ https://www.nhs.uk/medicines/lactulose/side-effects-of-lactulose/
      4. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852716/
      5. ↑ https://www.chop.edu/health-resources/food-medicine-probiotic-foods
      6. ↑ https://www.ncbi.nlm.nih.gov/pubmed/18542039
      7. ↑ https://my.clevelandclinic.org/departments/digestive/medical-professionals/hepatology/hepatic-encephalopathy#treatment-tab
      8. ↑ https://www.vcuhealth.org/news/new-study-shows-liver-patients-see-benefits-after-going-meatless-for-one-meal
      9. ↑ https://my.clevelandclinic.org/departments/digestive/medical-professionals/hepatology/hepatic-encephalopathy#treatment-tab
      10. ↑ https://pubmed.ncbi.nlm.nih.gov/11779097/
      11. ↑ https://pubmed.ncbi.nlm.nih.gov/1505922/
      12. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1496761/
      13. ↑ https://pubmed.ncbi.nlm.nih.gov/18059593/
      14. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777432/
      15. ↑ https://medlineplus.gov/lab-tests/ammonia-levels/

      About This Article

      Article Summary X

      Increased ammonia levels in your body can be the result of your liver not functioning properly, but by making dietary changes and taking medication, you can reduce them. Probiotics contain good bacteria that help your body digest food, so try eating foods high in probiotics, like yogurt or sauerkraut. You could also try eating more vegetables, like beans carrots, and broccoli, instead of red meat, since vegetable proteins release ammonia more slowly because they take longer to digest. High levels of ammonia can often be linked to medical conditions, like liver disease or hepatitis. That’s why it’s important to consult with your doctor, who will test your ammonia levels and make a treatment plan. They may prescribe you lactulose, which is a medication that can help your body get rid of ammonia. For tips from our Medical co-author on how to use supplements to reduce your ammonia levels, keep reading!

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