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If you have heartburn, acid reflux, ulcers, or gastroesophageal reflux disease (GERD), your doctor might prescribe pantoprazole. This proton pump inhibitor works by blocking the production of acid in your stomach. You'll need to take tablets or an oral solution for a few weeks before seeing an improvement in your symptoms. Fortunately, if you take it before your morning meal, there are few side effects and you should feel relief from your stomach acid troubles.

Method 1
Method 1 of 3:

Taking the Tablets

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  1. Prescription pantoprazole usually comes in 40mg tablets and your doctor will tell you to take 1 or 2 tablets a day depending on what health condition you're treating. [1]
    • For example, if you have GERD or stomach ulcers, you may need to take 20mg to 40mg a day. If you're treating Zollinger-Ellison syndrome, you'll take 40mg to 80mg a day.

    Did You Know? You can buy over-the-counter (OTC) pantoprazole in a lower dose to treat mild stomach acid problems. These tablets are sold as pantoprazole and contain 20mg instead of 40mg.

  2. The medication will work more successfully on an empty stomach, so try to take your tablet 1 hour before breakfast. This will give the medicine time to shut down the acid pumps that cause heartburn before you start eating. Studies show that taking pantoprazole in the morning is more effective than taking it in the evening. [2]
    • If you're supposed to take pantoprazole twice a day, take a dose in the morning before breakfast and another 1 hour before dinner. Try to time the dosages so they're 12 hours apart.
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  3. Instead of crushing, chewing, or breaking the tablet, swallow it whole with water. This will help the medication break down in your stomach properly. Crushing the medication can make the pantoprazole release too quickly in your stomach. [3]
    • If you struggle to swallow the coated tablets, ask your doctor about taking liquid pantoprazole.
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Method 2
Method 2 of 3:

Mixing Liquid Pantoprazole

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  1. If you can't swallow pantoprazole tablets, your doctor can prescribe liquid pantoprazole. When you get the medication from the pharmacy, the pantoprazole will be granular and in several pouches. Each pouch will be 40mg once you properly rehydrate the granules. [4]
    • Keep in mind that you should never divide the amount in the pouch. If the doctor prescribes the liquid pantoprazole, it's because you'll need to get at least a full 40mg a day.
    • The granule form is also good for people with Percutaneous endoscopic gastrostomy (PEG) tubes who can’t take anything by mouth.
  2. Since you'll need to mix up and measure your own liquid medication, ask the pharmacist for an oral medication syringe or medicine spoon so you can get an accurate dose. [5]
    • Avoid using a standard kitchen spoon for measuring the juice since these aren't precise.
  3. Use the syringe or spoon to measure the juice into a small cup and pour the granules from 1 pouch into it. Stir the mixture for 5 seconds and then drink it. To ensure you're getting all of the medication, pour another 1 teaspoon (4.9 ml) of apple juice in the cup and swirl it a little before drinking it. [6]
    • The drug manufacturer insists that you don't mix the granules in water or any other liquid.
    • The granules will not dissolve completely in the juice.

    Variation: You can also dilute the granules in 1 teaspoon (5 g) of applesauce instead of apple juice.

  4. Since liquid pantoprazole begins working faster than pantoprazole tablets, you only need to wait 30 minutes after taking the pantoprazole before eating. [7]
    • If you need to take 2 doses of pantoprazole a day, take your first dose in the morning and your second dose about 30 minutes before dinner.
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Method 3
Method 3 of 3:

Using Pantoprazole Effectively

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  1. Let your doctor know if you're allergic to any medication, if you have liver problems, if you have lupus, or if you're scheduled to have an endoscopy within a month. [8]
    • You should also tell your doctor if you're allergic to foods, dyes, or preservatives.
    • Pantoprazole is often prescribed for people over 12 years old.

    Tip: It's important to let your doctor know which medications you're currently taking. Some antibiotics, HIV medications, cancer treatments, and salts for anemia can interact with pantoprazole.

  2. You might also experience other mild side effects, which include diarrhea, dry mouth, or nausea. These should go away once you stop taking the medication. Let your doctor know if you have any of these more serious side effects: [9]
    • Allergic reaction
    • Dizziness
    • Difficulty breathing
    • Muscle spasms
    • Irregular heartbeat
  3. If you forget to take your pantoprazole in the morning, take it as soon as you remember. Then, take the following dose at the normal time. Avoid waiting for the next dose to take twice the recommended amount. [10]
    • If you remember the missed dose and you're supposed to take the next dose in less than 12 hours, skip the missed dose.

    Tip: If you typically take pantoprazole twice in a day, take the skipped dose as soon as you remember, unless you're supposed to take the second dose in less than 4 hours.

  4. Cut back on alcohol and caffeine . Although you can still drink alcohol and caffeinated beverages while taking pantoprazole, these can cause your stomach to make more acid. Higher levels of stomach acid can make your acid reflux or heartburn worse. [11]
    • The Centers for Disease Control recommends limiting your daily alcohol intake to 1 drink for women or 2 drinks for men.
    • Rich, fried, or spicy foods can also make your stomach symptoms worse so try to limit these foods.
  5. Let your doctor know if the symptoms you're treating with pantoprazole have gotten better. If so, your doctor might have you keep taking pantoprazole. If it doesn't seem to be working, your doctor may adjust your dosage or change medications. [12]
    • Sometimes, you might start with a high dose of pantoprazole and then your doctor will reduce your dose after 1 to 2 months.
  6. Keep the medication in its original container and put it somewhere out of direct light. The pantoprazole should be kept at room temperature and away from moisture, so you might want to put it on a high shelf instead of in the refrigerator or bathroom. [13]
    • If you have leftover pantoprazole that you don't plan on taking, return it to the pharmacy so they can dispose of it properly.
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      Tips

      • There are many other medicines that fulfill the same role as pantoprazole, such as omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), esomeprazole (Nexium), dexlansoprazole (Dexilant).
      • Always let your doctor know if you're taking natural herbs or supplements since some of these, such as St John's wart, can make pantoprazole ineffective.
      • Pantoprazole, like other protein pump inhibitors, might have some long term risks, such as risk of fractures, pneumonia, Clostridium difficile diarrhea, low magnesium, low vitamin B12, chronic kidney disease, and dementia.
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      Warnings

      • Although pantoprazole is safe to use if you're breastfeeding, you shouldn't take it if you're pregnant. Talk with your doctor about taking omeprazole instead.
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