Q&A for How to Beat Bio–Weapon Brutal Mode in Plague Inc.

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Why don't you don't activate HEAT 1? I've followed the steps, but the hot, arid countries are the last to get infected, and are much slower when they do. What should I do?

Community Answer

Start in a hot country such as Saudi Arabia. When you start in a hot country, you automatically get some heat resistance.

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Question

Which is the Annihilate gene?

Community Answer

The Annihilate gene is the gene in the middle of the three ability columns, it has a biohazard symbol on it.

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Question

I can't find the Annihilate gene?

Community Answer

You need to get all of the bio-weapon’s special abilities. These are Deactivate Modified Genes 1-3, Nucleic Acid Neutralization 1-3, and Gene Compression 1-3. Once you get all of those abilities, the Annihilate gene is unlocked and shows up on the abilities. This ability immediately makes your bio-weapon extremely lethal, even without normal lethal symptoms.

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Question

Can this strategy work without genes?

Community Answer

Probably not. You need to get the genes to get the annihilate gene in the middle.

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Question

Why doesn't this work?

MidnightTheBunny

Community Answer

It takes a lot of practice. I am still trying to beat Bacteria on Normal. It's best to look at the article multiple times, then try it out, so that you know how to play it to win.

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Question

How does this work on a PC?

Community Answer

The only difference is you can't evolve before you select a starting country.

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Question

Why do you need symptoms if you are going to kill everyone (along with cure resistance)?

Astro_Firey

Community Answer

You don't need symptoms really. You can just use the lethality given. The games can be tight though, so be careful.

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