REVIEW OF CLINICAL TRIALS OF DIABETES TREATMENT 2 Abstract Diabetes Mellitus in its common forms (types 1 & 2) affects more than 26 million Americans. The disease is the result of low or non-existent insulin production, or insulin tolerance, respectively. Long term nerve and vascular damage can occur in patients with uncontrolled blood glucose levels. Treatments focus on reducing and stabilizing blood glucose levels. Intensive management programs often include insulin treatments, as well as weight, nutrition, and educational components. Broad consensus exists in consumer-oriented literature about general diabetes management, although scientific trials are generally more focused. In order to present comprehensive management strategies, the author has attempted to synthesize findings from 28 research articles. The purpose of this study is to present a systematic review of the available evidence-based literature concerning the clinical question. The clinical question investigated is: For an adult patient with diabetes, what comprehensive management practices lead to controlled HbA1c? It is hoped this study will inform practitioners and patients about management practices for gaining HbA1c control.