How to Fill a Syringe

PDF download Download Article
PDF download Download Article

Medical professionals all over the world know how to fill a syringe, but the skill is increasingly becoming one that patients and their families need to know as well. Many people prefer to give themselves, or family members, injections at home rather than receive them in a clinical setting. Simply stick the needle through the rubber seal of your medication vial, turn the bottle upside down, and pull back the plunger to draw liquid into the syringe. To expel air bubbles, push the medication back into the vial, then redraw. Learning the proper technique to fill a syringe from a qualified medical professional and paying close attention to safety measures can help you take care of your medical condition in the privacy of your home.

Filling a Syringe from a Vial

  1. Remove the vial cap and wipe the rubber seal with rubbing alcohol.
  2. Pull the plunger of the syringe back to the desired measurement mark.
  3. Remove the needle cover and insert the needle into the rubber seal
  4. Push the plunger in to expel air from the syringe and turn the vial upside down.
  5. Pull the plunger back to draw liquid into the syringe.
  6. Push the liquid back into the vial and redraw it to eliminate air bubbles.
  7. Remove the needle from the vial.
Part 1
Part 1 of 4:

Preparing to Fill the Syringe

PDF download Download Article
  1. You will need the medication vial, syringe-needle unit, alcohol pads, a cotton ball, a band-aid, and a sharps container. [1]
    • The alcohol pad is used to wipe the rubber top of the medication container once you remove the outer seal. You may also need to clean the area of the skin where the injection will be administered.
    • The bandage and cotton ball are used to cover the area of the skin where you injected the medication to reduce bleeding.
    • The sharps container is the thick plastic bin that holds the used supplies, including the syringes and needles. When you use a lancet, syringe, or needle, these items are called sharps. Proper storage of used sharps is a safety measure. When the containers are full, they can be transferred to a place that destroys biohazard equipment. [2]
    • Each state and/or city may have their own protocol for disposing biohazard material/sharps disposal sites. Contact local health department for specific instructions on how to dispose of hazardous materials.
  2. If the injection you are giving is something other than insulin, the product literature that comes with the medication provides precise instructions on preparing the drug for administration. However, this literature should be considered a refresher and not the sole source of information — it is very important that a qualified medical professional trains you on preparation and how to administer the medication. If you have not received this training, you should not try to give someone an injection.
    • Not all medications are packaged the same way. Some medications need to be reconstituted with water before administration, while others may require using only the syringe and needle that comes with the product. Be thoroughly familiar with the steps you need to take that are specific to the medication.
    • Most injections given at home, other than insulin, will be done using a single dose vial. The label will say either single dose vial, or will contain the abbreviation, SDV.
    • This means that that only one dose can be given from that vial, regardless of the amount remaining after you have withdrawn the amount of medication you need.
    • In some cases, you may be administering a medication that is packaged in a vial called a multi-dose-vial. The package label will have the words multi-dose vial or the abbreviation MDV. Insulin vials are considered a multi-dose vial. [3] However, this is rare for medication intended for home use.
    • If you are using a multi-dose vial, write the date, using a marker that will not wipe off, when the container is first opened.
    • This type of product usually contains small amounts of preservatives, but still should not be used at all once 30 days after the first date of opening has passed, unless your doctor advises you differently. Keep these products in the refrigerator, but not frozen, between uses.
    Advertisement
  3. In order to maintain your safety, check the medication vial for several elements: [4]
    • Be sure you have the right medicine, and it is the right strength. [5]
    • Be sure the expiration date has not passed. [6]
    • Be sure the product has been stored according to the manufacturer’s guidelines. For example, some products can be stored at room temperature, while others may need refrigeration.
    • Check the integrity of the packaging. Make sure there are no cracks or dents in the vial that holds the medication.
    • Look for particulate matter. This means you must examine the medication in the vial to be sure nothing unusual is floating inside the container.
    • Examine the seal. Make sure there are no cracks or dents in the seal around the top of the vial.
    4. Advertisement
Part 2
Part 2 of 4:

Filling the Syringe

PDF download Download Article
  1. Be sure the syringe and needle have not deteriorated or been damaged.
    • Visible cracks in the barrel, or discoloration of any part of the syringe, including the rubber top on the plunger, indicates the syringe should not be used.
    • Examine the needle for damage. Check the needle to be sure it is not broken or bent. Do not use any product that appears to have been damaged.
    • While some packaged syringes have a visible expiration date, many do not. If you are not sure, contact the manufacturer. Have any lot numbers available when you call.
    • Discard damaged or deteriorated syringes safely in a sharps container.
  2. Do not interchange syringe types. Using the wrong type of syringe can easily result in giving the wrong amount of medication. [7]
    • Insulin syringes are intended for insulin administration only. The markings along the barrel are in units, and are specific for insulin dosing.
    • Your syringe should be able to hold a little more than the required amount for the dose. The needle should be the correct length for the type of injection you are going to administer.
    • Your doctor or pharmacist should have trained you on proper administration of the drug, including the type of syringe and needle recommended. You can use the product literature as a reference as well, but only once you have received adequate training.
    • If you have any questions, talk to your doctor or pharmacist. They can help you to be sure you have the correct syringe-needle unit for the medication you are giving.
  3. Safety syringes have a patented way to safely recap the needle once the medication has been drawn up. Practice this method prior to drawing up the actual dose of medication. This helps you to be prepared to re-cap the needle in situations where you do not give the prepared dose immediately. [8]
    • Discard the practice syringe safely in a sharps container.
    • It is generally not recommended to re-cap syringes, as this can result in accidental needle sticks.
  4. Thoroughly clean your hands using soap and water. Include washing your nail area, and between your fingers.
  5. Some medication, like insulin that appears cloudy, need to be gently mixed before drawing it up. Roll the medication between your hands gently. Do not shake it, as this will create bubbles. The product literature will advise you on products that should be gently mixed. [9]
  6. Wipe the rubber seal with an alcohol pad. Allow the alcohol to air-dry. Do not fan it with your hand or blow on it. Doing this may contaminate the cleaned area. [10]
  7. Your target is the line, or mark on the barrel, that is equal to the amount of medication you need to draw up. [11]
  8. Use caution not to touch the needle.
  9. Use a straight motion as you push the needle into the top of the medicine bottle. [12]
  10. This forces the air from the syringe into the bottle. You are inserting the amount of air that equals the amount of medication you will be removing. [13]
  11. Do this carefully so as not to dislodge the needle from the bottle. Hold the neck of the bottle between your thumb and index finger of your non-dominant hand. Support the syringe with your other hand. Do not allow the needle to bend. [14]
  12. Use your dominant hand to pull the plunger back to the line marked on the barrel of the syringe indicating the prescribed amount of medication. Do not remove the needle from the medication vial yet. [15]
  13. Gently tap the barrel of the syringe. This will move any air bubbles trapped in the medication toward the needle. [16]
  14. Once the air bubbles are at the top of the syringe, push the plunger until the air bubbles are removed. A small amount of medication may squirt out as you remove the air bubbles. [17]
  15. Once you have removed the air bubbles, check the amount of medication remaining in the syringe to be sure you have the exact dose you need.
  16. Avoid touching the needle once you have drawn the medication into the syringe. If you do not plan to give the injection immediately, then place a safety cover, as practiced, back on the needle. [18]
    • If you do not have a safety re-cap feature, carefully use the needle to scoop up the original needle covering. Then you can secure it in place with your fingers. [19]
  17. Injection techniques vary depending on the type of injection being given.
  18. According to the World Health Organization, there are 4 areas of focus in giving injections safely. [20] Those 4 areas include:
    • Avoid giving unnecessary injections.
    • Always use sterile equipment, including the needles.
    • Avoid contaminating the injection as it is prepared.
    • Properly dispose of the used syringes and needles.
  19. Once the injection has been given, discard of the needle in a sharps container. [21]
    • A needle that has pierced the skin of someone is not only dulled, but contaminated with possibly serious and contagious diseases.
    20. Advertisement
Part 3
Part 3 of 4:

Discarding Items Used in a Safe Manner

PDF download Download Article
  1. Sharps containers are designed to be a safe way to dispose of syringes and needles. Sharps containers are available for purchase at your local pharmacy, or online. [22]
    • Never put syringes or needles in the regular trash. [23]
    • If you do not have access to a sharps container, then you can use a container made from very thick plastic that has a tight-fitting lid, such as an empty laundry detergent container. Label the container with the words "Sharps Biohazard" and take it to a sharps disposal location when it is full. [24]
  2. Many states have specific recommendations and programs that can help you develop a regular system for disposing of biohazardous waste. Sharps, including used needles and syringes, are considered to be biohazardous waste since they came in direct contact with someone's skin or blood. [25]
  3. Some companies offer to supply you with the appropriate sizes of sharps containers, and agree to set up an arrangement for you to safely mail those containers back to them when they are full. The company will dispose of the biohazard materials appropriately, according to EPA, FDA, and state requirements. [26]
  4. Some states have specific guidelines regarding the disposal of unused medications.
    • In many cases, you may able to place the opened vials of medication directly into the sharps containers. Your pharmacy, physician, mailback company, or state agency, can advise you on the proper disposal of unused medication. [27]
    5. Advertisement
Part 4
Part 4 of 4:

Understanding the Basics

PDF download Download Article
  1. Syringes are categorized by how their parts work and how they are designed to function.
  2. Common syringes most recently used in clinical practice are called luer-lok syringes. Luer-lok describes the type of locking mechanism built into the tip of the syringe. The mechanism works by securely holding luer-lok needles once they are twisted in place.
    • Using this type of syringe requires an added step in assembly. The added step is to secure the needle to the syringe, prior to drawing up the medication.
  3. Examples of syringe types that are designed for a certain purpose or function include an insulin syringe, tuberculin syringe, and safety syringe.
    • Insulin syringes are intended only for giving insulin. The barrel is graduated in units instead of mls.
    • Tuberculin syringes are used when you need to give a very small dose of a medication, such as 0.5mls.
  4. A safety syringe is an all-in-one unit. That means that the syringe has a pre-attached needle, so the added step of attaching the needle by hand is not needed.
    • A safety syringe also has a built-in mechanism that either covers, or retracts, the needle once the medication has been administered to the patient.
    • Due to the increasing number of healthcare accidents involving needle sticks, regulatory agencies are mandating the use of safety syringes in healthcare facilities. Safety syringes are recommended by health organizations including the CDC and the World Health Organization. [28]
  5. A syringe is made of 3 basic parts. Those parts include the barrel, the plunger, and the tip.
  6. The barrel is the clear part in the middle that holds the medication. The barrel is marked with numbers and lines in a graduated manner. These help to guide you as you fill the syringe. The inside of the barrel is considered to be a sterile environment.
    • The numbers indicate the amount of medication you are putting in the syringe in mls, or ccs. The abbreviation “mls” stands for milliliters. The abbreviation “ccs” stands for cubic centimeters.
    • ONE ml is the same as ONE cc.
    • The numbers and lines on an insulin syringe indicate the units of insulin being drawn into the syringe. Insulin syringes usually have a graduated measurement in mls also, but this is in smaller or lighter type. The focus of an insulin syringe is to provide clarity regarding the number of insulin units being drawn up.
  7. The plunger is the part of the syringe that you manipulate as you fill the syringe. The end of the plunger extends out from the bottom of the syringe, and gently glides inside the barrel. This action helps you to accurately draw up the correct amount of medication.
    • The rubber tip of the plunger that slides inside the barrel is considered sterile. The lower part of the plunger extends from the bottom of the syringe. This is the also the part you push to deliver the medication when you give the injection.
  8. The tip of the syringe is where the needle is attached. For reasons of safety and convenience, safety syringes, or all-in-one syringes, are available with the needle already attached.
    • Using a luer-lok syringe requires attaching the needle. This type of syringe, and the separate needle, have grooves that allow for the needle to be securely attached to the tip of the syringe with a simple twisting motion.
  9. The needle attaches to the tip of the syringe and has 3 parts. Those parts include the hub, shaft, and bevel.
    • The hub is the part closest to the barrel where the needle connects to the syringe.
    • The shaft is the longest part of the needle.
    • The bevel is the very tip of the needle that comes in direct contact with the skin of the person receiving the injection. Needles are designed to have a slight slant, or bevel, on the very tip.
  10. Many drugs that must be administered by injection are now being packaged by the manufacturers in kits that contain everything you would need, including the syringe and needle.
    • If you need to purchase the syringe-needle combo unit separately from the medication, try to find safety syringes that will work for the medication and delivery site needed.
    • Syringes can be purchased separately from needles, but for safety reasons this is not recommended. Even hospitals are being mandated to use safety syringe-needle combo units to avoid complications that include a greater risk of infections for the patients and needle stick injuries that may occur to the staff.
  11. In order to select the correct syringe, it is important that you understand what you need to properly fill the syringe and give the injection. An all-in-one syringe needle unit will have 3 distinct numbers on the package labeling.
    • One of the numbers indicates the size of the syringe barrel, such as 3cc. A second number will give the length of the needle, such as 1 inch. The third number indicates the gauge of the needle, such as 23g.
    • Always select a syringe that holds more than you need to inject. If your medication requires that you inject 2cc, same as 2mls, for each dose, then you will want to choose a syringe that is larger, say a 3cc, or 3ml, syringe.
    • The needle length is specific to the place where the medication needs to be delivered. Something that needs to just go under the skin would require a shorter needle, such as ½ to ¾ inch. If you need to get the medication delivered into a muscle, you will need to select a longer needle size.
    • The size of the person receiving the injection is also something to consider. Obese people may need a longer needle to reach a muscle than people with less body fat.
    • The gauge of the needle tells you how fat the needle is. It is actually a measure of the diameter of the hole inside the needle. Some medications are thicker and need a fatter needle to properly pass the medication through it and into the skin. Other medications can be given using a skinnier needle.
    • The numbers that tell you the gauge of the needle are backwards. The larger numbers indicate the smaller actual diameter of the needle.
    • Using an 18 gauge needle would allow for a thicker medication to pass through easily, but it also might hurt a little more. A 23 gauge needle has a smaller diameter for the medication to pass through.
    • Try to select the smallest thickness, or diameter, of the needle, meaning a higher number, that will work with the medication you need to inject. Remember, the larger the number, the smaller the thickness or diameter.
  12. Syringes hold medications that are intended to be given by injection. Injections can be given by 3 primary routes. [29]
    • Subcutaneous injections are a common type of injection administered at home. Insulin is administered in a subcutaneous manner.
    • IM, or intramuscular injections, are more complicated than giving a subcutaneous injection. This is the type of injection that requires getting the medication delivered into muscle tissue.
    • The final route is called intravenous. This is not a common route of administration, unless someone has an indwelling venous catheter, or they are in a hospital setting. IV medication should never be administered at home unless through a port-a-cath and patient's have been trained sufficiently. This is very dangerous and if done incorrectly, can introduce bacteria into blood stream, thus causing systemic deadly infection.
    13. Advertisement

Common Questions: Injecting Air into Veins Accidentally

What happens if you accidentally inject air into the vein?

Air entering your vascular system is called an air embolism. Air embolisms are rare, but can be fatal or cause serious damage. The air in your veins may cause an obstruction in your lungs or hearts in severe cases. Embolisms in arteries are typically more dangerous than in veins. [30]

Can an air embolism resolve itself?

If the embolism is quite small and in a vein (not an artery), it may dissipate on its own without medical intervention. However, embolisms in arteries can be immediately fatal. [31]

How painful is an air embolism?

The pain and symptom severity of an embolism depend on the quantity of air inside the veins. Very small embolisms can go unnoticed, while severe embolism can cause instant cardiac collapse. Other symptoms include chest pain, dyspnea, headache, and confusion. [32]

Tips

  • Practice. If you plan to routinely give yourself, or someone in your family, injections, practice until you are comfortable. It takes patience, a clear head, and manual dexterity to safely take on the task of giving medications by injection. Use the actual syringes you will be working with, and practice with a vial of sterile water or normal saline. Be sure to safely discard your practice materials.
    Thanks
    Helpful 0 Not Helpful 0
  • Once you have mastered filling the syringe, practice giving the injections into fruit. Ripe oranges work well.
    Thanks
    Helpful 0 Not Helpful 0
  • Don’t hesitate to call the manufacturer if you have questions. Many injectable medications now come in either prefilled syringes, or kits that have all the contents you need to give the injection at home. Sometimes things may not make sense if you are new to filling syringes and giving injections.
    Thanks
    Helpful 0 Not Helpful 0
Show More Tips
Submit a Tip
All tip submissions are carefully reviewed before being published
Name
Please provide your name and last initial
Submit
Thanks for submitting a tip for review!
Advertisement

Warnings

  • Always put safety first. If you are not sure if you accidentally touched the needle while filling the syringe, or notice something in the medication vial after you have drawn up the accurate dose, waste that round and start again.
    Thanks
    Helpful 4 Not Helpful 0
  • Again, you should not be administering any injections unless you have received thorough training from a qualified heath care professional. Simply reading the product literature, reading a how-to, or watching a video online is not enough.
    Thanks
    Helpful 3 Not Helpful 3
  • If the plunger comes all the way out of the syringe, then discard that syringe. Once the inside of the barrel part of the syringe has been exposed to room air, it is no longer a sterile environment.
    Thanks
    Helpful 2 Not Helpful 2
Advertisement

Video

You Might Also Like

How to
Read Syringes
Administering B12 Injections Safely at Home: A Complete Guide
How to
Inject Yourself: 13 Ways to Stay Safe and Sterile
How to
Give an Intramuscular Injection
How to
Give a Subcutaneous Injection
How to
Give a Prolia Injection
How to
Avoid Bruises from Injections
How to
Administer IV Fluids
How to
Give a Newborn an IM Injection
How to
Reduce Pain After an Injection
How to
Give a Heparin Shot
How to
Perform a Self Injection to the Abdomen
How to
Give an Injection
How to
Make Shots Pain-Free: Effective Distraction and Relaxation Strategies for Adults & Children
Advertisement

References

  1. ↑ https://medlineplus.gov/ency/patientinstructions/000530.htm
  2. ↑ https://www.fda.gov/medical-devices/safely-using-sharps-needles-and-syringes-home-work-and-travel/best-way-get-rid-used-needles-and-other-sharps
  3. ↑ https://www.bd.com/resource.aspx?IDX=3866
  4. ↑ https://medlineplus.gov/ency/patientinstructions/000530.htm
  5. ↑ https://www.bd.com/resource.aspx?IDX=3866
  6. ↑ https://www.cdc.gov/injectionsafety/providers/provider_faqs_multivials.html
  7. ↑ https://www.bd.com/resource.aspx?IDX=3866
  8. ↑ https://essr.umd.edu/sites/default/files/2021-11/NeedleRecappingFactSheet.pdf
  9. ↑ https://www.bd.com/resource.aspx?IDX=3866
  1. ↑ https://medlineplus.gov/ency/patientinstructions/000530.htm
  2. ↑ https://www.stjude.org/treatment/patient-resources/caregiver-resources/patient-family-education-sheets/home-care-guidelines/withdrawing-medicine-from-a-vial.html
  3. ↑ https://www.stjude.org/treatment/patient-resources/caregiver-resources/patient-family-education-sheets/home-care-guidelines/withdrawing-medicine-from-a-vial.html
  4. ↑ https://www.stjude.org/treatment/patient-resources/caregiver-resources/patient-family-education-sheets/home-care-guidelines/withdrawing-medicine-from-a-vial.html
  5. ↑ https://www.stjude.org/treatment/patient-resources/caregiver-resources/patient-family-education-sheets/home-care-guidelines/withdrawing-medicine-from-a-vial.html
  6. ↑ https://www.stjude.org/treatment/patient-resources/caregiver-resources/patient-family-education-sheets/home-care-guidelines/withdrawing-medicine-from-a-vial.html
  7. ↑ https://medlineplus.gov/ency/patientinstructions/000530.htm
  8. ↑ https://medlineplus.gov/ency/patientinstructions/000530.htm
  9. ↑ https://medlineplus.gov/ency/patientinstructions/000530.htm
  10. ↑ https://medlineplus.gov/ency/patientinstructions/000530.htm
  11. ↑ https://www.cdc.gov/oralhealth/infectioncontrol/faqs/safe-injection-practices.html
  12. ↑ https://www.cdc.gov/injection-safety/about/
  13. ↑ https://www.fda.gov/medical-devices/safely-using-sharps-needles-and-syringes-home-work-and-travel/sharps-disposal-containers
  14. ↑ https://www.fda.gov/medical-devices/safely-using-sharps-needles-and-syringes-home-work-and-travel/dos-and-donts-proper-sharps-disposal
  15. ↑ https://www.fda.gov/downloads/MedicalDevices/ProductsandMedicalProcedures/HomeHealthandConsumer/ConsumerProducts/Sharps/UCM382038.pdf
  16. ↑ https://www.fda.gov/medical-devices/consumer-products/safely-using-sharps-needles-and-syringes-home-work-and-travel
  17. ↑ https://www.recyclespot.org/how-to-recycle/health-and-fitness/prescriptions-and-medications
  18. ↑ https://www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/HomeHealthandConsumer/ConsumerProducts/Sharps/
  19. ↑ https://www.cdc.gov/injection-safety/hcp/clinical-guidance/index.html
  20. ↑ https://www.drugs.com/article/injection-types-sites.html
  21. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126790/
  22. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126790/
  23. ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665124/

About This Article

Article Summary X

To fill a syringe, first pull the plunger back to your desired measurement. Then, insert the needle into the top of your medicine bottle and depress the plunger to expel air from the syringe. Next, carefully turn the bottle upside-down and pull the plunger back to your chosen measurement. Once you've done that, tap the barrel of the syringe to shift any air bubbles toward the needle. Finally, if there are any bubbles in the syringe, push the plunger gently to remove them. For more tips from our Medical co-author, including how to follow health and safety precautions when using syringes, read on!

Did this summary help you?
In other languages
Thanks to all authors for creating a page that has been read 333,201 times.

Reader Success Stories

  • R. R.

    Mar 5, 2017

    "Very helpful for my students in Somalia, your website summarize clearly."
Share your story

Did this article help you?

Advertisement