Q&A for How to Beat Prion Brutal Mode in Plague Inc.

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The cure keeps rising fast, and I used two of the things next to the pills (not the potion stuff).

Community Answer

If you are talking about genetic shuffle, it does not slow down the cure; it only gets rid of most of the progress. Evolve symptoms that have "significantly makes research harder" in their descriptions.

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I followed every single step here carefully, and I lost and only took 40% of the world with me. I evolved every symptom that significantly makes research harder, but the cure still became 100% complete. Why did this happen?

Community Answer

You need to put all available points into stopping the cure, because this type of plague develops symptoms slowly and kills more slowly too. More patience at the start (only plane/ship transmissions and cold 1) means you have more to spend at the end on cure avoidance and developing symptoms, which make a cure harder to research.

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Question

What happens if I need the genetic reshuffle 3?

Community Answer

Just buy it if you have enough DNA points to have some left after doing so.

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How do I beat Prion Brutal Mode in Plague Inc. if I don't have those genes?

Community Answer

Play through the game on any difficulty to unlock genes; just play through casually enough and you’ll get them all.

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Question

I followed your advice to the letter, but when the borders were shutting, Greenland and Morocco were still uninfected. Why is this?

MidnightTheBunny

Community Answer

It's alright to try to start in Greenland or Morocco, if you wish.

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