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The most effective, medically-backed ways to reduce SGPT and reverse or prevent liver damage
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Serum glutamate pyruvate transaminase (SGPT), now called alanine aminotransferase (ALT), is a liver enzyme that is vital for energy production. When the liver is damaged, SGPT leaks out of the cells and into your blood, raising levels above the normal range of about 4 to 36 units per liter (U/L) of blood. High levels of SGPT (or ALT) in the blood may indicate liver problems and damage, and you may be at risk of high SGPT if you abuse alcohol, use certain medications, or have a liver condition such as viral hepatitis or liver cancer. If you’ve ruled out all serious causes and you’re concerned about consistently high SGPT levels, the right diet, lifestyle modifications, and possible medical treatment may bring your numbers down to normal within a few weeks or months.
Lowering ALT (SGPT) Levels
At least 150 minutes of exercise a week can lower ALT levels in adults to reverse or prevent liver damage. You can also lower your ALT levels by eating nutritious food rich in vitamin D, fiber, and antioxidants. Cut back on oils, processed foods, and salt.
Steps
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Eat more vitamin D-rich foods. Vitamin D prevents liver damage (which reduces SGPT levels in the bloodstream), and those with high levels of vitamin D are less vulnerable to liver disease than those with low levels of vitamin D. Include at least 1 fruit and vegetable in each major meal to have a daily dose of vitamin D, staving off liver disease. [1] X Trustworthy Source PubMed Central Journal archive from the U.S. National Institutes of Health Go to source
- Incorporate good sources of vitamin D into your diet like green, leafy vegetables, cod liver oil, fish, fortified cereals, oysters, caviar, tofu, soy milk, dairy products, eggs, mushrooms, apples, and oranges.
- Spend more time in the sunshine, too. The sun’s UV rays stimulate vitamin D production in your skin (make sure to wear sunscreen to prevent sunburn).
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Eat a nutritious, fiber-rich, plant-based diet. Eating organic foods helps the liver cleanse itself of toxins and create new cells to stop SGPT leaking into the blood. Consume more fresh, whole foods that you’ve prepared yourself and stay away from high-sugar or processed foods, which are often lacking nutrients. Focus on foods high in fiber, antioxidants, vitamins, and minerals. [2] X Trustworthy Source PubMed Central Journal archive from the U.S. National Institutes of Health Go to source
- Eat a variety of fresh fruits and vegetables, especially leafy greens like spinach and cruciferous vegetables like cauliflower, broccoli, and cabbage.
- Aim to get 20-30 grams of fiber per day from sources like whole grains, beans, and lentils.
- Include more antioxidant-rich foods like wild blueberries, carrots, potatoes, beetroot, and avocado.
- Replace red or fatty meat with lean protein like chicken and fish, switch to low-fat dairy products, and snack on nutritious nuts and seeds over processed foods like potato chips.
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Reduce your intake of high-fat, oily, and fried foods significantly. Fatty foods make it hard for the liver to process nutrients. Having more than 10% liver fat is a condition called fatty liver disease, which can lead to inflammation and damage to your liver tissue (resulting in higher SGPT levels in your blood). However, foods rich in Omega-3 fatty acids, like salmon, may help lower SGPT and promote liver health. To reduce liver fat, cut back on foods like: [3] X Research source
- Oily foods that are deep fried
- Fatty cuts of meat like sausage, bacon, or pork and chicken skins
- Coconut oil
- High-fat dairy products like butter or cheese
- Highly processed junk food
- Aerated or carbonated drinks that are high in sugar
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Add less salt to your cooking and buy low-sodium grocery items. Excessive salt, especially in the liver, causes swelling and fluid retention. This makes it harder for the liver to filter waste, leading to liver damage and raised SGPT levels. [4] X Trustworthy Source American Chemical Society Scientific society for those involved with chemistry and publisher of several leading peer-reviewed scientific journals Go to source The average adult only needs 2,300 mg of sodium (about 1 teaspoon) per day, so avoid adding extra salt to your dishes and do more cooking at home to control your sodium intake.
- Limit high-sodium foods like bouillon cubes, baking soda, soy sauce, salad dressings, bacon, salami, pickled foods, and processed foods.
- Look for low-sodium or unsalted versions of foods like soy sauce or snacking nuts at the grocery store.
- To add flavor to your cooking, opt for more herbs and spices instead of an extra pinch of salt.
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Stay hydrated and drink more herbal teas. Drinking lots of water helps the liver flush away toxins and repair itself, reducing the amount of SGPT that filters into your blood. Aim to drink filtered water when you wake up, between meals, and in the evening to keep your body and liver hydrated. [5] X Research source
- Aim to drink 15.5 cups (3.7 liters) of water per day for men, or 11.5 cups (2.7 liters) for women. [6] X Trustworthy Source Mayo Clinic Educational website from one of the world's leading hospitals Go to source
- Add lemon juice to your water for a boost of liver-cleansing citric acid and vitamin C. A pinch of turmeric in a glass of water or milk can also have anti-inflammatory benefits for your liver.
- Drink more herbal teas like green tea, chamomile, dandelion root, or milk thistle. [7] X Trustworthy Source Mayo Clinic Educational website from one of the world's leading hospitals Go to source Studies show these may have protective benefits against liver disease. [8] X Trustworthy Source PubMed Central Journal archive from the U.S. National Institutes of Health Go to source
- Coffee has also been shown to reduce fat accumulation in the liver and promote antioxidant capacity. [9] X Trustworthy Source PubMed Central Journal archive from the U.S. National Institutes of Health Go to source
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Stop drinking alcohol until your SGPT levels are normal. Alcohol is very harmful to the liver. When alcohol is ingested, it goes directly to the bloodstream and makes its way to the liver, which must filter out the toxins from alcohol. Over time, regular heavy drinking can create serious liver damage that allows more SGPT to enter your bloodstream. [10] X Research source
- Cut out alcohol entirely until your SGPT levels return to the normal range (this can take several weeks or months depending on the cause). Follow your doctor’s instructions about when or if you can begin drinking again.
- After your levels have stabilized, enjoy alcoholic drinks in moderation if you wish. Medically, moderation is defined as 2 drinks or less per day for men or 1 drink or less for women. [11] X Trustworthy Source Centers for Disease Control and Prevention Main public health institute for the US, run by the Dept. of Health and Human Services Go to source
- Alcohol consumption is a major contributor to liver diseases such as fatty liver, liver cirrhosis, and hepatitis, as well as increased SGPT levels. Speak to your doctor or a therapist if your drinking habits are affecting your health or you’re struggling to reduce your alcohol intake.
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Try to lift weights or get aerobic exercise 3 or more days a week. Studies show that both resistance training and aerobic activity are equally effective at lowering liver fat and enzyme levels, including SGPT. Aim to lift weights or engage in aerobic workouts like brisk walking, jogging, or swimming for about 45 minutes a day, at least 3 days a week to see lower SGPT levels in as little as 8 weeks. [12] X Trustworthy Source PubMed Central Journal archive from the U.S. National Institutes of Health Go to source
- Exercise is beneficial for your overall well-being, including your liver health. Staying active excretes toxins in the body through sweating and burns fat, leaving your liver with more energy to dedicate to strengthening its cells.
- Exercise may not be as effective at reversing liver fat accumulation and increased enzymes caused by excessive alcohol consumption.
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Quit smoking . Smoke from cigarettes contains toxins like nicotine and ammonia that your liver must filter out, and studies show a strong correlation between smoking and elevated SGPT levels—the more you smoke, the higher your liver enzyme levels. Quit smoking gradually or cold turkey to lower SGPT, and avoid secondhand smoke as much as possible. [13] X Research source
- Quitting smoking is beneficial to your overall health as well, especially for your heart, lungs, kidneys, skin, hair, and nails.
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Wear protective gear to prevent exposure to harmful chemicals. Certain chemicals can cause elevated SGPT levels and a liver condition called toxic hepatitis (swelling of the liver due to chemical exposure). [14] X Trustworthy Source Cleveland Clinic Educational website from one of the world's leading hospitals Go to source These include fumes from gasoline or ammonia, carbon-based organic solvents like benzene, or synthetic “forever” chemicals like per- and polyfluoroalkyl substances (PFAS). [15] X Trustworthy Source National Institutes of Health U.S. government agency for biomedical and public health research Go to source If you must be around toxic fumes for work, wear long sleeves, pants, a mask , and gloves at all times. [16] X Trustworthy Source Cleveland Clinic Educational website from one of the world's leading hospitals Go to source
- These toxins can be absorbed through your skin, inhaled as fumes, or even consumed through food and drink in the case of some PFAS.
- The more precautions you take, the healthier you’ll be in the long-term.
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Work on losing weight if you are overweight or obese. If you struggle with weight issues, you may be at risk of developing fatty liver, which can lead to elevated SGPT levels. Talk to your doctor about safe and effective ways to manage your weight, or ask them to refer you to a registered dietitian. [17] X Trustworthy Source Mayo Clinic Educational website from one of the world's leading hospitals Go to source
- Talk to your doctor about what types of diet and exercise are healthy and appropriate for you. For most people, aim to get at least 150 minutes of exercise per week and center your diet around fresh produce and whole foods. [18] X Trustworthy Source Harvard Medical School Harvard Medical School's Educational Site for the Public Go to source
- In certain cases, weight loss surgery or medication may be recommended to improve your liver and overall health.
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Measure your SGPT level with a blood test at the doctor’s office. A comprehensive metabolic panel or a liver panel will detect levels of SGPT (also known as alanine transaminase, or ALT) in your bloodstream. In cases of acute liver damage, SGPT levels rise dramatically as the enzyme leaks through cell walls into your blood. Elevated levels may be due to recent strenuous activities, exercise, or alcohol consumption, so let your doctor know if you’ve participated in these activities prior to getting your blood drawn. [19] X Trustworthy Source Cleveland Clinic Educational website from one of the world's leading hospitals Go to source
- High SGPT is not a sign of liver damage on its own. It must be considered with other liver tests to verify whether a patient really suffers from damage to the liver.
- Different underlying causes might cause different levels of SGPT elevation. For example, nonalcoholic fatty liver disease is the leading cause of mild SGPT elevation in the U.S. Mild SGPT elevation can also be associated with strenuous exercise or thyroid disease.
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Stop taking over-the-counter drugs and supplements if possible. If your liver is already damaged and you continue taking non-prescription drugs, the liver may sustain further damage as it metabolizes additional medication. These drugs include non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, pain relief medicines like acetaminophen, and more. If your SGPT is high, only take drugs your doctor recommends or prescribes. [20] X Trustworthy Source Cleveland Clinic Educational website from one of the world's leading hospitals Go to source
- If in doubt, ask your physician about non-hepatotoxic (nontoxic to the liver) drugs or which over-the-counter drugs are OK to take.
- Be particularly careful about using medications that contain acetaminophen. Acetaminophen can raise SGPT levels and is a common component in many OTC medications.
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Consider corticosteroids to lower SGPT and prevent liver damage. This medication decreases inflammation in and around the liver by reducing the production of inflammatory chemicals to lessen tissue damage. Corticosteroids can be taken orally or can be injected through a vein. The most common corticosteroids are Hydrocortisone, Prednisone, and Fludrocortisone. [21] X Trustworthy Source National Institute of Diabetes and Digestive and Kidney Diseases Health information from the National Institute of Diabetes and Digestive and Kidney Diseases, a division of the U.S. National Institutes of Health Go to source
- Once the inflammation subsides, the liver cells will start to regenerate, therefore decreasing the release of SGPT into the bloodstream. If your SGPT levels drop, it means you’re responding well to the medication.
- Talk to your doctor about starting corticosteroids. No medication should be started without a doctor’s approval.
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Take prescribed antiviral medications if high SGPT is due to a virus. Some viruses, like those that cause hepatitis, can damage your liver and cause a spike in SGPT. After a blood test, your physician will know what virus is the underlying cause of the infection and will prescribe antiviral medications such as Entecavir, Sofosbuvir, Telaprevir and others. [22] X Trustworthy Source PubMed Central Journal archive from the U.S. National Institutes of Health Go to source
- Antiviral medications work in the same manner as corticosteroids. Once the infection is eradicated, the liver cells will start to regenerate, reducing the release of SGPT into the bloodstream.
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Talk to your doctor about taking interferons for certain liver conditions. Interferon therapy and medications trigger the protective defenses of the body’s immune system to kill foreign bodies such as viruses, bacteria, tumor cells, or parasites that damage the liver and raise SGPT levels. If successful, SGPT starts decreasing once the infection is eradicated. [23] X Trustworthy Source PubMed Central Journal archive from the U.S. National Institutes of Health Go to source
- With treatment, the liver cells will start to regenerate, regularizing your SGPT levels. With new cells, SGPT cannot leak into your bloodstream.
- Interferons can cause a wide variety of side effects, such as dizziness, hair loss, reduced appetite, exhaustion, difficulty breathing, and flu-like symptoms. Always talk to your doctor about potential risks and side effects before starting any new medical treatment.
- Interferons may be used to treat hepatitis C, hepatocellular carcinoma, and other conditions. [24] X Trustworthy Source PubMed Central Journal archive from the U.S. National Institutes of Health Go to source
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Consider taking herbal supplements. Medications paired with herbal supplements may help lower SGPT levels. Talk to your doctor to see if any supplements are safe and appropriate for you. Consider some of the following supplements:
- Milk thistle may prevent and repair liver damage from toxic chemicals and harmful medications. It’s available in 100mg to 1000mg forms. The standard dosage of milk thistle is 200mg, 2 to 3 times a day. [25] X Trustworthy Source Mayo Clinic Educational website from one of the world's leading hospitals Go to source
- Inositol helps the liver in breaking down fats, but may cause abdominal pain and diarrhea. A typical dose is 500mg, 3 times a day. [26] X Research source
- Burdock root helps cleanse the liver and prevent further damage. It’s available in 500mg to 1000mg forms. A typical dose is 500mg, 3 times a day. [27] X Trustworthy Source PubMed Central Journal archive from the U.S. National Institutes of Health Go to source
- Keep in mind that most evidence for the efficacy of these supplements comes from animal testing, and more research is needed to confirm the benefits for humans.
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Aim to lower your SGPT levels to the normal range of 4 to 36 U/L. The “normal” range differs from laboratory to laboratory and depends on the method used to measure it. The normal range for SGPT levels for most men and women is 4 to 36 international units (U) per liter (L). [28] X Research source
- Values that are significantly higher (greater than 15 times the upper limit of normal) may indicate hepatitis.
- Moderately higher values (5-15 times the ULN) may indicate severe burns, cirrhosis, obstructive jaundice, or liver tumors.
- Slightly higher values (less than 5 times the ULN) may indicate pancreatitis, shock, infectious mononucleosis, or heart attack.
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References
- ↑ http://www.ncbi.nlm.nih.gov/pubmed/24272594
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5615029/
- ↑ https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/liver-fatty-liver-disease
- ↑ https://www.acs.org/pressroom/presspacs/2016/acs-presspac-february-24-2016/too-much-salt-could-potentially-contribute-to-liver-damage.html
- ↑ https://www.sfadvancedhealth.com/blog/6-simple-ways-to-detox-your-liver
- ↑ https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/water/art-20044256
- ↑ https://www.mayoclinic.org/drugs-supplements-milk-thistle/art-20362885
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538013/
- ↑ https://pubmed.ncbi.nlm.nih.gov/25291138/
- ↑ https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-12-145
- ↑ https://www.cdc.gov/alcohol/about-alcohol-use/moderate-alcohol-use.html
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644631/
- ↑ https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-12-145
- ↑ https://my.clevelandclinic.org/health/diseases/17915-toxic-hepatitis
- ↑ https://www.nih.gov/news-events/nih-research-matters/study-links-synthetic-chemicals-liver-damage
- ↑ https://my.clevelandclinic.org/health/diseases/17915-toxic-hepatitis
- ↑ https://www.mayoclinic.org/diseases-conditions/nonalcoholic-fatty-liver-disease/symptoms-causes/syc-20354567
- ↑ https://www.health.harvard.edu/blog/weight-loss-can-help-head-off-lasting-damage-caused-by-fatty-liver-2020043019664
- ↑ https://my.clevelandclinic.org/health/diagnostics/22028-alanine-transaminase-alt
- ↑ https://my.clevelandclinic.org/health/diagnostics/22028-alanine-transaminase-alt
- ↑ https://www.niddk.nih.gov/health-information/liver-disease/autoimmune-hepatitis/treatment
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4979821/
- ↑ https://pubmed.ncbi.nlm.nih.gov/8943974/
- ↑ https://pubmed.ncbi.nlm.nih.gov/23564522/
- ↑ https://www.mayoclinic.org/drugs-supplements-milk-thistle/art-20362885
- ↑ https://www.mdpi.com/2072-6643/12/11/3379
- ↑ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564434/
- ↑ http://www.nlm.nih.gov/medlineplus/ency/article/003473.htm
About This Article
Article Summary
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To lower your SGPT, or serum glutamate pyruvate transaminase, increase your vitamin D intake by either taking a supplement or eating foods such as leafy green vegetables, fish, and dairy products. Avoid foods that are high in sodium or fat, like fried foods, bacon, and carbonated drinks, as these can lead to inflammation of your liver. You should also avoid drinking alcoholic beverages, as these can increase the damage to your liver and raise your SGPT levels even more. Keep reading to learn the kinds of medications your doctor may prescribe to lower your SGPT!
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- "I am 23 years old, I was alcoholic during my teenage days. Last year I got my SGPT test because I thought I was suffering from arthritis, specifically I got painful hands and feet. I got my first result 3 times higher than normal, and my physician recommend having another test from a different clinic and still got same results. I haven't taken drugs and I don't usually taking medicines whenever I'm not feeling well. I took other tests and, thank God, the results were fine. My physician advised that he will just observe. I searched for articles that could educate and help me since it's getting higher. The article helped me a lot and gave more ideas on how to start, what to do, aware of the foods I eat, and others. Now I'm going to set my goal to lower those results. Thanks, wikiHow. This article lessens my worry and gave me hope in curing my illness! :)" ..." more
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"I am 23 years old, I was alcoholic during my teenage days. Last year I got my SGPT test because I thought I was suffering from arthritis, specifically I got painful hands and feet. I got my first result 3 times higher than normal, and my physician recommend having another test from a different clinic and still got same results. I haven't taken drugs and I don't usually taking medicines whenever I'm not feeling well. I took other tests and, thank God, the results were fine. My physician advised that he will just observe. I searched for articles that could educate and help me since it's getting higher. The article helped me a lot and gave more ideas on how to start, what to do, aware of the foods I eat, and others. Now I'm going to set my goal to lower those results. Thanks, wikiHow. This article lessens my worry and gave me hope in curing my illness! :)"
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"Thank you so much and God bless you! I did almost the same thing, just vegetables, fruits, egg and plenty of water. Also, I exercise fifteen to thirty minutes a day by running, but I did not take any medicine. Now my SGPT level is normal. I did this in just nine days. It used to be 132! I'm just sharing my experience because this really works."
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"I was freaking out when my doctor informed me that my SGPT level was high, honestly I did not know what it meant until I found the full information on this website, as well as how to get back to a normal level. Thank you very much, this is truly a useful tool."
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"Yes, it helps me in general and in particular depending upon the questions that are in the mind. Also it goes a long way to satisfy/calm down, the lay man regarding many an unfounded apprehensions about a healthy liver. Articles are simple and lucid. Thanks!"
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"Doctors do not explain what your disease is, and you are at your wit's end trying to figure it out. This site is so clear about every detail of what is happening in your body, what can happen in the future, and the precaution to be taken. Absolute clarity."
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