How to Reduce Protein in Urine

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Protein in urine is never a normal thing (when the levels are above 150 mg per day, which is when your doctor will tell you that you have abnormal levels of protein in your urine). There are times when you have elevated protein only transiently, and it may resolve on its own; however, if the problem is ongoing or particularly severe, you will need to seek medical help. Protein in the urine is often a sign of underlying kidney disease, or of other medical problems if it continues for more than a few days. [1] [2]

Part 1
Part 1 of 2:

Trying Lifestyle and Medical Treatments

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  1. [3] Lifestyle strategies to reduce your blood pressure include:
    • Decreasing the salt in your diet. To do so, avoid excess table salt on foods prepared at home. Perhaps more importantly, avoid eating out too frequently, or consuming too many processed foods, as these are known to be high in salt (significantly more so, on average, than foods prepared at home).
    • Cutting back on cholesterol. Cholesterol build-up contributes to plaques forming in your arteries, which in turn leads to increased blood pressure. Ask your doctor for blood tests to measure your fat and cholesterol levels to see if this is an area of your diet that could use improvement.

    Note: Elevated blood pressure puts a lot of strain on the kidneys, and since persistent proteinuria (elevated protein in the urine) is almost always linked to a problem in the kidneys, reducing your blood pressure can help the problem significantly.

  2. [4] Essentially everyone who is diagnosed with a level of kidney disease or kidney dysfunction (which are the primary reasons for persistently elevated protein in the urine) receives a blood pressure medication from their doctor. Specifically, the ideal one for doctors to prescribe is an "ACE inhibitor" (an angiotensin-converting enzyme inhibitor). Examples include ramipril, captopril, and lisinopril. The benefit of this specific class of blood pressure medication is that it has an additional benefit (and a "protective effect") for your kidneys.
    • Ask your doctor about receiving a prescription for this medication if you are not taking it already.
    • You may need more than one blood pressure medication in more severe cases of kidney disease.
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  3. [5] For instance, if you have an underlying autoimmune disease causing kidney problems (and hence protein in your urine), you may need medications to suppress your immune system. If your kidney troubles (and proteinuria) are complications of diabetes, you may need medications such as metformin or insulin to obtain better daily control of your blood sugar levels. There are many potential diagnoses that could lead to kidney trouble and resulting proteinuria, so speak with your doctor to come up with the best medical management for your specific case.
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Part 2
Part 2 of 2:

Evaluating The Cause

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  1. It is important to understand that the only way to reduce or treat protein in your urine is by diagnosing the underlying cause. [6] [7] This is because protein in the urine is not a diagnosis in itself. Rather, it is a symptom indicating that something else is going on. It is only in the diagnosing and treating of that "something else" that the elevated protein level can be addressed and dealt with.
  2. [8] There are three types of proteinuria, and the good news is that two of the three require no treatment and usually resolve on their own with time. The third type, however, requires a more comprehensive medical examination to determine the underlying cause. The three types are:
    • Transient proteinuria: This is when a urine test reveals elevated protein on one reading, but the level diminishes on its own and returns to normal with subsequent readings. [9] Transient proteinuria is normally related to acute stresses such as an illness that causes a fever or more exercise than usual (such as training for a marathon). Once the stress passes or your body adapts to it, your protein levels should also return to normal.
    • Orthostatic proteinuria: This is when the abnormal protein levels are related to postural changes (standing versus sitting versus lying down). [10] It is uncommon and more likely to be present in adolescents. If present, it does not require treatment and almost always resolves itself by adulthood.
    • Persistent proteinuria: This is when the protein levels in your urine remain elevated after repeated testing. [11] It is indicative of an underlying problem such as kidney disease, diabetes, autoimmune disease, or another medical condition. It requires a series of tests for diagnostic purposes as well as medical treatment.
  3. [12] As previously mentioned, if you are currently ill with a fever, exercising more than usual, or suffering from other acute stressors in your life, the protein levels in your urine may be elevated transiently as a result. See your doctor again a few days after your first test for a repeat urine test, at which point they can confirm if your protein levels have diminished or returned to normal. If you are experiencing "transient proteinuria," there is nothing you need to do to treat it. Your levels will return to normal on their own within a few days to a couple of weeks.
  4. [14] It is important to obtain a series of measurements of the protein level in your urine to see how it is progressing and whether or not it is improving on its own. Your doctor may offer you a urine test to do in the washroom in their clinic, or they may ask you to take it home and to return it to the lab once you have collected the urine sample. If you store your urine at home, keep it cool in the refrigerator until you are able to deliver it to the lab for formal analysis.
  5. [15] Additional diagnostic testing that your doctor may perform includes blood tests, particularly if they suspect that you may have underlying kidney disease or other health problems. If your doctor orders blood tests, they will likely be measuring BUN (blood urea nitrogen) and creatinine levels. [16] Both of these are kidney function tests, providing your doctor with valuable information about the health of your kidneys.
    • Your doctor may also order other blood tests to measure HbA1c (a diabetes indicator) or autoimmune antibodies if they suspect an underlying autoimmune disease.
    • The tests your doctor performs depend on your medical history and the medical conditions that your doctor thinks you are most at risk of having.
  6. In some cases, a kidney biopsy is also required as a further investigation to determine the cause of the protein in your urine. [17] This is rare, but it may be needed if your doctor cannot otherwise determine the cause.
  7. If you are currently pregnant and have elevated protein levels, it may be due to a condition called preeclampsia. Read How to Deal With Preeclampsia for more information on preeclampsia and elevated protein levels in your urine during pregnancy.
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Expert Q&A

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  • Question
    How do they diagnose elevated protein in urine?
    Robert Dhir, MD
    Board Certified Urologist & Urological Surgeon
    Dr. Robert Dhir is a board certified Urologist, Urological Surgeon, and the Founder of HTX Urology in Houston, Texas. With over 10 years of experience, Dr. Dhir’s expertise includes minimally-invasive treatments for enlarged prostate (UroLift), kidney stone disease, surgical management of urological cancers, and men’s health (erectile dysfunction, low testosterone, and infertility). His practice has been named a Center of Excellence for the UroLift procedure, and is a pioneer in non-surgical procedures for ED using his patented Wave Therapy. He earned his undergraduate and medical degrees from Georgetown University and was awarded honors in pre-medical studies, urology, orthopedics, and ophthalmology. Dr. Dhir served as chief resident during his urological surgical residency at University of Texas at Houston / MD Anderson Cancer Center in addition to completing his internship in general surgery. Dr. Dhir was voted Top Doctor in Urology for 2018 to 2019, one of the top three Best Rated Urologists in 2019 & 2020 for Houston Texas, and Texas Monthly has named him to the 2019 & 2020 Texas Super Doctors Rising Stars list.
    Robert Dhir, MD
    Board Certified Urologist & Urological Surgeon
    Expert Answer
    Typically, your doctor will order a urine test to analyze glucose and protein levels in your urine. If protein is found, they may refer you to a specialist for further tests to diagnose the underlying issue.
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  • Question
    What food and precautions should be taken for the above?
    Chris M. Matsko, MD
    Family Medicine Physician
    Dr. Chris M. Matsko is a retired physician based in Pittsburgh, Pennsylvania. With over 25 years of medical research experience, Dr. Matsko was awarded the Pittsburgh Cornell University Leadership Award for Excellence. He holds a BS in Nutritional Science from Cornell University and an MD from the Temple University School of Medicine in 2007. Dr. Matsko earned a Research Writing Certification from the American Medical Writers Association (AMWA) in 2016 and a Medical Writing & Editing Certification from the University of Chicago in 2017.
    Chris M. Matsko, MD
    Family Medicine Physician
    Expert Answer
    You are going to want to eat a healthy diet low in protein, trans fats, and salt. Try to limit your salt intake as this can lead to hypertensive renal disease.
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  • Question
    Which medicine is best for protein leakage?
    Chris M. Matsko, MD
    Family Medicine Physician
    Dr. Chris M. Matsko is a retired physician based in Pittsburgh, Pennsylvania. With over 25 years of medical research experience, Dr. Matsko was awarded the Pittsburgh Cornell University Leadership Award for Excellence. He holds a BS in Nutritional Science from Cornell University and an MD from the Temple University School of Medicine in 2007. Dr. Matsko earned a Research Writing Certification from the American Medical Writers Association (AMWA) in 2016 and a Medical Writing & Editing Certification from the University of Chicago in 2017.
    Chris M. Matsko, MD
    Family Medicine Physician
    Expert Answer
    Normally if you are a diabetes they give you an ACE inhibitor or an Angiotensin Receptor Blocker to reduce the nephropathy.
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      References

      1. ↑ Robert Dhir, MD. Board Certified Urologist & Urological Surgeon. Expert Interview. 23 September 2020.
      2. ↑ https://emedicine.medscape.com/article/238158-overview
      3. ↑ https://www.uptodate.com/contents/protein-in-the-urine-proteinuria-beyond-the-basics
      4. ↑ https://www.uptodate.com/contents/the-nephrotic-syndrome-beyond-the-basics
      5. ↑ https://www.uptodate.com/contents/glomerular-disease-beyond-the-basics
      6. ↑ Robert Dhir, MD. Board Certified Urologist & Urological Surgeon. Expert Interview. 23 September 2020.
      7. ↑ https://emedicine.medscape.com/article/238158-overview
      8. ↑ https://www.uptodate.com/contents/protein-in-the-urine-proteinuria-beyond-the-basics
      9. ↑ https://www.uptodate.com/contents/protein-in-the-urine-proteinuria-beyond-the-basics
      1. ↑ https://www.uptodate.com/contents/protein-in-the-urine-proteinuria-beyond-the-basics
      2. ↑ https://www.uptodate.com/contents/protein-in-the-urine-proteinuria-beyond-the-basics
      3. ↑ https://www.uptodate.com/contents/protein-in-the-urine-proteinuria-beyond-the-basics
      4. ↑ Robert Dhir, MD. Board Certified Urologist & Urological Surgeon. Expert Interview. 23 September 2020.
      5. ↑ https://emedicine.medscape.com/article/238158-overview
      6. ↑ https://emedicine.medscape.com/article/238158-overview
      7. ↑ https://www.uptodate.com/contents/protein-in-the-urine-proteinuria-beyond-the-basics
      8. ↑ https://www.uptodate.com/contents/protein-in-the-urine-proteinuria-beyond-the-basics

      About This Article

      Article Summary X

      To reduce protein in your urine, you'll need to diagnose the underlying cause by determining which type of proteinuria you are experiencing, since some types, like orthostatic proteinuria, will resolve on their own. For example, if your doctor tests your urine multiple times and finds elevated protein levels on more than one reading, it could be a sign of an underlying condition such as kidney disease, diabetes, or an autoimmune disorder. If you have persistent proteinuria because of a kidney problem, consider making lifestyle changes to reduce your blood pressure by decreasing your salt and cholesterol intake. In some cases, your doctor may also recommend blood pressure medication or other medical treatments, such as medication to suppress your immune system. For more tips from our Medical co-author, including how to deal with transient proteinuria, keep reading.

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